Pair Name	Oxymatrine, Paclitaxel
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Biological Phenomena	Induction-->Apoptosis
Gene Regulation	Down-regulation	Expression	BCL2	hsa596
	Down-regulation	Expression	BCL-xL	hsa598
	Down-regulation	Expression	BIRC2	hsa329
	Down-regulation	Expression	BIRC3	hsa330
	Down-regulation	Expression	BIRC5	hsa332
	Up-regulation	Cleavage	CASP3	hsa836
	Down-regulation	Expression	COX2	hsa4513
	Down-regulation	Phosphorylation	JAK1	hsa3716
	Down-regulation	Phosphorylation	JAK2	hsa3717
	Down-regulation	Expression	MMP9	hsa4318
	Up-regulation	Cleavage	PARP1	hsa142
	Down-regulation	Phosphorylation	SRC	hsa6714
	Down-regulation	Phosphorylation	STAT5A	KEGG ID N.A.
	Down-regulation	Expression	VEGFA	hsa7422
In Vitro Model	NCI-H1299	Lung large cell carcinoma	Homo sapiens (Human)	CVCL_0060
	A-549	Lung adenocarcinoma	Homo sapiens (Human)	CVCL_0023
In Vivo Model	In a preclinical lung cancer mouse model, OMT when used in combination with paclitaxel produced a significant reduction in tumor volume.
Result	Oxymatrine Attenuates Tumor Growth and Deactivates STAT5 Signaling in a Lung Cancer Xenograft Model